Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Petrova, Veselina; Pearson, Craig S.; Ching, Jared; Tribble, James R.; Solano, Andrea; Yang, Yunfei; Love, Fiona; Watt, Robert; Osborne, Andrew; Reid, Evan; A. Williams, Pete; Martin, Keith R.; Geller, Herbert M.; Eva, Richard; W. Fawcett, James

doi:10.6084/m9.figshare.13144886.v1

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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

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posted on 2020-10-28, 18:40 authored by Veselina Petrova, Craig S. Pearson, Jared Ching, James R. Tribble, Andrea Solano, Yunfei Yang, Fiona Love, Robert Watt, Andrew Osborne, Evan Reid, Pete A. Williams, Keith R. Martin, Herbert M. Geller, Richard Eva, James W. Fawcett

In this study, we describe the use of a scaffolding protein, Protrudin to boost axon regeneration and neuroprotection in the adult central nervous system. Our work reveals a novel mechanism of axon regeneration where Protrudin-induced axon regeneration is dependent on its interaction with the endoplasmic reticulum and other axon transport molecules. This data opens up new avenues to explore novel therapeutic targets for conditions of the central nervous system such as glaucoma, spinal cord injury and brain injury.